@article {7484,
	title = {The genomic substrate for adaptive radiation in African cichlid fish},
	journal = {Nature},
	volume = {513},
	year = {2014},
	pages = {375-381},
	abstract = {Cichlid fishes are famous for large, diverse and replicated adaptive radiations in the Great Lakes of East Africa. To understand themolecularmechanisms underlying cichlid phenotypic diversity,wesequenced the genomesand transcriptomes of five lineages of Africancichlids: theNile tilapia (Oreochromis niloticus), an ancestral lineagewith low diversity; and four members of the East African lineage: Neolamprologus brichardi/pulcher (older radiation, Lake Tanganyika), Metriaclima zebra (recent radiation, LakeMalawi),Pundamilia nyererei (very recent radiation, LakeVictoria), andAstatotilapia burtoni (riverine species around Lake Tanganyika).Wefound an excess of gene duplications in the East African lineage compared to tilapia and other teleosts, an abundance of non-coding element divergence, accelerated coding sequence evolution, expression divergence associated with transposable element insertions, and regulation by novel microRNAs. In addition, we analysed sequence data from sixty individuals representing six closely related species from Lake Victoria, and show genome-wide diversifying selection on coding and regulatory variants, some of which were recruited fromancient polymorphisms. Weconclude that a numberof molecular mechanisms shaped East African cichlid genomes, and that amassing of standing variation during periods of relaxed purifying selectionmayhave been important in facilitating subsequent evolutionary diversification.},
	url = {http://www.nature.com/nature/journal/v513/n7518/pdf/nature13726.pdf},
	author = {Brewand, D. and Wagner, C.E. and Li, Y.I. and Malinsky, M. and Keller, I. and Fan, S. and Simakov, O. and Ng, A.Y. and Lim, Z.W. and Bezault, E. and Turner-Maier, J. and Johnson, J. and Alcazar, R. and Noh, H.J. and Russell, P. and Aken, B. and Alfodi, J. and Amemiya, C. and Azzouzi, N. and Baroiller, J.F. and Barloy-Hubler, F. and Berlin, A. and Bloomquist, R. and Carleton, K.L. and Conte, M.a. and D{\textquoteright}Cotta, H. and Eshel, O. and Gaffney, L. and Galibert, F. and Grante, H.F. and Gnerre, S. and Greuter, L. and Guyon, R. and Haddad, N.S. and Haerty, W. and Harris, R. M. and Hofmann, H. A. and Hourlier, T. and Hulata, G. and Jaffe, D.B. and Lara, M. and Lee, A.P. and MacCallum, I. and Mwaiko, S. and Nikaido, M. and Nishihara, H. and Ozouf-Costaz, C. and Penman, D.J. and Przybylski, D. and Rakotomanga, M. and Renn, S.C. and Ribeiro, F.J. and Ron, M. and Salzburger, W and Sanchez-Pulido, L. and Santos, M.E. and Searle, S. and Sharpe, T. and Swofford, R. and Tan, F.J. and Williams, L. and Young, S. and Yin, S and Okada, N. and Kocher, T.D. and Miska, E.a. and Lander, E.S. and Venkatesh, B. and Fernald, R D and Meyer, A. and Ponting, C.P. and Streelman, J.T. and Lindblad-Toh, K. and Seehausen, O. and Di Palmer, F.}
}
