@article {7360,
	title = {Androgens coordinate neurotransmitter-related gene expression in male whiptail lizards},
	journal = {Genes, Brain and Behavior},
	volume = {11},
	number = {7},
	year = {2012},
	month = {2012///},
	pages = {813 - 818},
	abstract = {Sex steroid hormones coordinate neurotransmitter systems in the male brain to facilitate sexual behavior. Although neurotransmitter release in the male brain has been well documented, little is known about how androgens orchestrate changes in gene expression of neurotransmitter receptors. We used male whiptail lizards (Cnemidophorus inornatus) to investigate how androgens alter neurotransmitter-related gene expression in brain regions involved in social decision making. We focused on three neurotransmitter systems involved in male-typical sexual behavior, including the N-methyl-d-aspartate (NMDA) glutamate receptor, nitric oxide and dopamine receptors. Here, we show that in androgen-treated males, there are coordinated changes in neurotransmitter-related gene expression. In androgen-implanted castrates compared with blank-implanted castrates (control group), we found associated increases in neuronal nitric oxide synthase gene expression in the nucleus accumbens (NAcc), preoptic area and ventromedial hypothalamus, a decrease of NR1 gene expression (obligate subunit of NMDA receptors) in the medial amygdaloid area and NAcc and a decrease in D1 and D2 dopamine receptor gene expression in the NAcc. Our results support and expand the current model of androgen-mediated gene expression changes of neurotransmitter-related systems that facilitate sexual behavior in males. This also suggests that the proposed evolutionarily ancient reward system that reinforces sexual behavior in amniote vertebrates extends to reptiles.},
	keywords = {Androgens, dopamine receptors, glutamate, neuronal nitric oxide synthase, Sexual behavior},
	isbn = {1601-183X (Electronic)\r1601-183X (Linking)},
	author = {O{\textquoteright}Connell, L A and Mitchell, M M and Hofmann, H. A. and Crews, D}
}
