The Hofmann Lab
Mechanisms and Evolution of Social Decision Making
  • 2015


    Simões JM, Barata EN, Harris RM, Lauren A O’Connell, Hans A Hofmann, Rui F Oliveira (2015) Social odors conveying dominance and reproductive information induce rapid physiological and neuromolecular changes in a cichlid fish BMC Genomics 16:114. PDF


    Oldfield RG, Mandrekar K, Nieves MX, Hendrickson DA, Chakrabarty P, Swanson BO, Hofmann HA (2015) Parental care in the Cuatro Ciénegas cichlid, Herichthys minckleyi (Teleostei: Cichlidae). Hydrobiologica 748(1), 233-257. PDF


    Yin W, Maguire SM, Pham B, Garcia AN, Dang N, Liang J, Wolfe A, Hofmann HA, Gore AC (2015) Testing the Critical Window Hypothesis of Timing and Duration of Estradiol Treatment on Hypothalamic Gene Networks in Reproductively Mature and Aging Female Rats. Endocrinology. PDF


    Taborsky M, Hofmann HA, Beery AK, Blumstein DT, Hayes LD, Lacey EA, Martins EP, Phelps SM, Solomon NG, Rubenstein DR (2015) Taxon matters: promoting integrative studies of social behavior: NESCent Working Group on Integrative Models of Vertebrate Sociality: Evolution, Mechanisms, and Emergent Properties. Trends in Neuroscience 38(4), 189-191. PDF


    Harris RM, Hofmann HA (2015) Seeing is believing: Dynamic evolution of gene families. Proceedings of the National Academy of Sciences. 201423685. PDF


    Stiver KA, Harris RM, Townsend JP, Hofmann HA, Alonzo SH (2015) Neural Gene Expression Profiles and Androgen Levels Underlie Alternative Reproductive Tactics in the Ocellated Wrasse, Symphodus ocellatus. Ethology 121 (2), 152-167. PDF


    Smith CC, Harris RM, Lampert KP, Schartl M, Hofmann HA, Ryan MJ (2015) Copy number variation in the melanocortin 4 receptor gene and alternative reproductive tactics the swordtail Xiphophorus multilineatus. Environmental Biology of Fishes 98 (1), 23-33. PDF


  • 2014

    Hofmann HA, Beery AK, Blumstein DT, Couzin ID, Earley RL, Hayes LD, ... & Rubenstein DR (2014). An evolutionary framework for studying mechanisms of social behavior. Trends in Ecology & Evolution, 29(10), 581-589. PDF


    Brawand D, Wagner CE, Li YI, Malinsky M, Keller I, Fan S, ... & Rakotomanga, M (2014). The genomic substrate for adaptive radiation in African cichlid fish. Nature. PDF


    Weitekamp CA, Hofmann HA (2014) Evolutionary themes in the neurobiology of social cognition. Current Opinion in Neurobiology. 28:22-27. PDF


    Huffman LS, Hinz FI, Wojcik S, Aubin-Horth N, Hofmann HA. (2014) Arginine vasotocin regulates social ascent in the African cichlid fish Astatotilapia burtoni. General and comparative endocrinology. PDF


    Georg F Striedter, T Grant Belgard, Chun‐Chun Chen, Fred P Davis, Barbara L Finlay, Onur Güntürkün, Melina E Hale, Julie A Harris, Erin E Hecht, Patrick R Hof, Hans A Hofmann, Linda Z Holland, Andrew N Iwaniuk, Erich D Jarvis, Harvey J Karten, Paul S Katz, William B Kristan, Eduardo R Macagno, Partha P Mitra, Leonid L Moroz, Todd M Preuss, Clifton W Ragsdale, Chet C Sherwood, Charles F Stevens, Maik C Stüttgen, Tadaharu Tsumoto, Walter Wilczynski (2014). NSF workshop report: Discovering general principles of nervous system organization by comparing brain maps across species. J Comp Neurol. 522(7):1445-53. PDF


    Fischer EK, Harris RM, Hofmann HA, Hoke KL (2014) Predator exposure alters stress physiology in guppies across timescales. Hormones and Behavior 65:165–172. PDF


    Harris RM, Otopalik AG, Smith CJ, Bucher D, Golowasch J and Hofmann HA. Single-Neuron Gene Expression Analysis Using the Maxwell® 16 LEV System in the Neural Systems and Behavior Course. Promega Corporation Web site. Html


    Harris RM, Hofmann HA (2014) Neurogenomics of behavioral plasticity. Adv Exp Med Biol. 781:149-68. PDF


    Harris RM, Dijkstra PD, Hofmann HA (2014) Complex structural and regulatory evolution of the pro-opiomelanocortin gene family. General and Comparative Endocrinology 195: 107–115. PDF

  • 2013


    O'Connell LA, Ding JH, Hofmann HA (2013) Sex differences and similarities in the neuroendocrine regulation of social behavior in an African cichlid fish. Hormones and Behavior, 64:468-476. PDF


    Kültz D, Clayton DF, Robinson GE, Albertson C, Carey HV, Cummings ME, Dewar K, Edwards SV, Hofmann HA, Gross LJ, Kingsolver JG,

    Meaney MJ, Schlinger BA, Shingleton AW, Sokolowski MB, Somero GN, Stanzione DC, Todgham AE (2013) New Frontiers for Organismal Biology. BioScience 63, 464-471. PDF


    Kidd MR, Dijkstra PD, Alcott C, Lavee D, Ma J, O’Connell LA, Hofmann HA. Prostaglandin F2α facilitates female mating behavior based on male performance. Behav Ecol Sociobiol, 67:1307-1315. PDF


    Sessa AK, Harris RM, Hofmann HA (2013) Sex Steroid Hormones Modulate Responses to Social Challenge and Opportunity in Males of the Monogamous Convict Cichlid, Amatitliana nigrofasciata. Gen Comp Endocrinol.189, 59–65. PDF


    Oldfield RG, Harris RM, Hendrickson DA, Hofmann HA (2013) Arginine Vasotocin and Androgen Pathways are Associated with Mating System Variation in North American Cichlid Fishes. Hormones and Behavior 64, 44–52. PDF


    O'Connell LA, Rigney MM, Dykstra DW, Hofmann HA (2013) Neuroendocrine Mechanisms Underlying Sensory Integration of Social Signals. J Neuroendocrinol 25, 644-654. PDF


    Huffman Lin S., O’Connell Lauren A., Hofmann HA (2013) Aromatase regulates aggression in the African cichlid fish Astatotilapia burtoni. Physiology & Behavior 112, 77–83. PDF


    Kidd MR, O'Connell LA, Kidd CE, Chen CW, Fontenot MR, Williams SJ, Hofmann HA (2013) Female preference for males depends on reproductive physiology in the African cichlid fish Astatotilapia burtoni. General and Comparative Endocrinology 180, 56-63. PDF


    O'Connell LA, Fontenot MR, Hofmann HA (2013) Neurochemical profiling of dopaminergic neurons in the forebrain of a cichlid fish, Astatotilapia burtoni. Journal of Chemical Neuroanatomy 47, 106-15. PDF

  • 2012


    O'Connell LA & Hofmann HA (2012) Evolution of a Vertebrate Social Decision-Making Network. Science 336, 1154-1157. PDF


    O'Connell LA & Hofmann HA (2012) Social Status Predicts How Sex Steroid Receptors Regulate Complex Behavior across Levels of Biological Organization. Endocrinology 153: 1341-1351. PDF Suppl


    Dijkstra PD, Schaafsma S, Hofmann HA, Groothuis T (2012) ‘Winner Effect’ without winning: Unresolved social conflicts increase the probability of winning a subsequent contest in a cichlid fish. Physiology & Behavior 105: 489-492. PDF


    O’Connell LA, Mitchell MM, Hofmann HA, Crews D (2012) Androgens coordinate neurotransmitter-related gene expression in male whiptail lizards. Genes, Brain, and Behavior. 11:813-818. PDF


    Desjardins JK, Hofmann HA, Fernald RD (2012)  Social context influences aggressive and courtship behavior in a cichlid fish. PLoS ONE. 7: 32781. PDF


    Huffman LS, O’Connell LA, Kenkel CD, Kline RJ, Khan IA, Hofmann HA (2012) Distribution of neuropeptide systems in the brain of an African cichlid fish, Astatotilapia burtoni. Journal of Chemical Neuroanatomy 44:86-97. PDF


    O’Connell LA, Matthews BJ, Hofmann HA (2012)  Isotocin regulates fatherhood in a monogamous cichlid fish. Hormones and Behavior 61:725–733. PDF


    Huffman LS, Mitchell MM, O’Connell LA, Hofmann HA (2012)  Rising StARs: Behavioral, hormonal, and molecular responses to social challenge and opportunity. Hormones and Behavior 61:631–641. PDF


    Dijkstra PD, Verzijden MN, Groothuis TGG, Hofmann HA (2012) Divergent hormonal responses to social competition in closely related haplochromine cichlid fish. Hormones and Behavior 61:518–526. PDF


    Renn SCP, Fraser EJ, Aubin-Horth N, Trainer BC, Hofmann HA (2012) Females of an African cichlid fish display male-typical social dominance behavior and elevated androgens in the absence of males. Hormones and Behavior 61:496–503. PDF


    Kidd MR, Duftner N, Koblmüller S, Sturmbauer C, Hofmann HA (2012)  Repeated parallel evolution of parental care strategies within Xenotilapia, a genus of cichlid fishes from Lake Tanganyika. PLoS ONE. 7:31236. PDF



  • 2011

    O’Connell LA, Hofmann HA (2011) The vertebrate mesolimbic reward system and social behavior network: A comparative synthesis. Journal of Comparative Neurology. 519:3599-639. PDF


    Dijkstra PD, Wiegertjes GF, Forlenza M, Sluijs I, Hofmann HA, Metcalfe NB, Groothuis TG (2011) The physiological cost of being red: Coloration, oxidative stress, immune function, hormones, and aggression in cichlid fish. Journal of Evolutionary Biology. 24:2639-52. PDF


    Kline RJ, O’Connell LA, Hofmann HA, Holt GJ, Khan IA (2011) The distribution of an AVT V1a receptor in the brain of a sex changing fish, Epinephelus adscensionis. Journal of Chemical Neuroanatomy 42:72-88. PDF


    Whitaker KW, Neumeister H, Preuss T, Hofmann HA (2011) Serotonergic modulation of startle-escape plasticity in an African cichlid fish: A single-cell molecular and physiological analysis of a vital neural circuit. Journal of Neurophysiology 106: 127–137. PDF


    O’Connell LA, Ding JH, Ryan MJ, Hofmann HA (2011) Neural distribution of the progesterone receptor in the túngara frog, Physalaemus pustulosus. Journal of Chemical Neuroanatomy 41:137-147. PDF


    O'Connell LA, Hofmann, HA (2011) Genes, hormones, and circuits: An integrative approach to study the evolution of social behavior. Frontiers in Neuroendocrinology 32:320–335. PDF


    Oldfield RG, Hofmann HA (2011) Neuropeptide regulation of monogamous behavior in a cichlid fish. Physiology & Behavior 102:296-303. PDF


    O'Connell LA, Fontenot M, Hofmann HA (2011) Characterization of the dopaminergic system in the brain of an African cichlid fish, Astatotilapia burtoni. Journal of Comparative Neurology 519:75–92. PDF

  • 2010

    Carone BR, Fauquier L, Habib N, Shea JM, Hart CE, Li R, Bock C, Li C, Zamore PD, Meissner A, Weng Z, Hofmann HA, Friedman N, Rando OJ (2010) Paternally-induced transgenerational environmental reprogramming of metabolic gene expression in mammals. Cell 143:1084–1096. PDF


    Neumeister H, Whitaker KW, Hofmann HA, Preuss T (2010) Social and ecological regulation of a decision-making circuit. Journal of Neurophysiology 104:3180-3188. PDF


    O’Connell LA, Matthews BJ, Ryan MJ, Hofmann HA (2010) Characterization of the dopamine system in the brain of the túngara frog, Physalaemus pustulosus. Brain, Behavior & Evolution 76:211-225. PDF


    O’Quin KE, Hofmann CM, Hofmann HA, Carleton KL (2010) Natural selection and the convergent evolution of opsin gene expression in African cichlids. Molecular Biology & Evolution 27: 2839-2854. PDF


    Hofmann HA (2010) The neuroendocrine action potential. Hormones & Behavior 58:555-562. PDF


    Wong RY, Hofmann HA (2010) Behavioural genomics: An organismic perspective. In: Encyclopedia of Life Sciences (ELS). John Wiley & Sons, Ltd: Chichester. PDF


    Munchrath LA, Hofmann HA (2010) Distribution of androgen, estrogen, and progesterone receptors in the brain of an African cichlid fish, Astatotilapia burtoni. Journal of Comparative Neurology 518:3302–3326. PDF


    Hofmann HA (2010) Early developmental patterning sets the stage for brain evolution. Proceedings of the National Academy of Sciences USA107:9919-9920. PDF


    Renn SCP, Machado H, Jones A, Soneji K, Kulathinal RJ, Hofmann HA (2010) Using comparative genomic hybridization to survey genomic sequence divergence across species: A proof-of-concept from Drosophila. BMC Genomics 11:271 (1-12). PDF


    Kidd C, Kidd MR, Hofmann HA (2010) Measuring multiple hormones from a single water sample using enzyme immunoassays. General & Comparative Endocrinology 165:277–285. PDF


  • 2009

    Machado H, Pollen AA, Hofmann HA, Renn SCP (2009) Interspecific profiling of gene expression informed by comparative genomic hybridization: A review and a novel approach in African cichlid fishes. Integrative & Comparative Biology 49:644 - 659. PDF


    Aubin-Horth N, Letcher BH, Hofmann HA (2009) Gene-expression signatures of Atlantic salmon’s plastic life cycle. General & Comparative Endocrinology163:278-284. PDF

  • 2008

    Pollen AA, Hofmann HA (2008) Beyond neuroanatomy: Novel approaches to studying brain evolution. Brain, Behavior & Evolution 72:145–158. PDF


    [This essay is part of a volume containing all papers contributed to the 19th Karger Workshop on "Neurobiological Lessons Learned from Comparative Studies: Evolutionary Forces Shaping Brain and Behavior", co-edited by Hans Hofmann and Caroly Shumway.]


    Renn SCP, Aubin-Horth N, Hofmann HA (2008) Fish & Chips: Functional genomics of social plasticity in an African cichlid fish. Journal of Experimental Biology 211:3041-3056. PDF


    Greenwood AK, Wark AR, Fernald RD, Hofmann HA (2008): Expression of arginine vasotocin in distinct preoptic regions is associated with dominant and subordinate behaviour in an African cichlid fish. Proceedings of the Royal Society B 275:2393–2402. PDF


    Salzburger W, Renn SCP, Steinke D, Braasch I, Hofmann HA, Meyer A (2008): Annotation of expressed sequence tags for the East African cichlid fish species Astatotilapia burtoni and evolutionary analyses of cichlid ORFs. BMC Genomics 9:96 (1-14). PDF


    Cummings ME, Larkins-Ford J, Reilly CRL, Wong RY, Ramsey M, Hofmann HA (2008): Sexual and social stimuli elicit rapid and contrasting genomic responses. Proceedings of the Royal Society B 275:393–402. PDF


    Duftner N, Larkins-Ford J, Legendre M, Hofmann HA (2008): Efficacy of RNA amplification is dependent on sequence characteristics: Implications for gene expression profiling using a cDNA microarray. Genomics 91:108-117. PDF


  • 2007

    Trainor BC, Hofmann HA (2007): Somatostatin and somatostatin receptor gene expression in dominant and subordinate cichlid fish. Behavioral Brain Research 179:314-320. PDF


    Shumway CA, Hofmann HA, Dobberfuhl AP (2007) A new technique for quantifying habitat complexity in freshwater or marine systems. Freshwater Biology 52:1065-1076. PDF


    Aubin-Horth N, Desjardins J, Martei Y, Balshine S, Hofmann HA (2007): Masculinized dominant females in a cooperatively breeding species. Molecular Ecology 16:1349–1358. PDF


    Pollen AA, Dobberfuhl AP, Scace J, Igulu MM, Renn SCP, Shumway CA, Hofmann HA (2007): Environmental complexity and social organization sculpt the brain in Lake Tanganyikan cichlid fish. Brain, Behavior & Evolution 70:21–39. PDF

  • 2006-1999

    Trainor BC, Hofmann HA (2006): Somatostatin regulates aggressive behavior in an African cichlid fish. Endocrinology, 147:5119–5125. PDF


    Hofmann HA (2006): GnRH signaling in behavioral plasticity. Current Opinion in Neurobiology 16:343-350. PDF


    Aubin-Horth N, Landry CR, Letcher BH, Hofmann HA (2005) Alternative life-histories shape different brain gene expression profiles in males of the same population. Proceedings of the Royal Society B, 272:1655-1662. PDF


    Aubin-Horth N, Letcher BH, Hofmann HA (2005) Interaction of rearing environment and reproductive tactic on gene expression profiles in Atlantic Salmon. Journal of Heredity 96: 261-278. PDF


    Renn SCP, Aubin-Horth N, Hofmann HA (2004) Biologically meaningful expression profiling across species using heterologous hybridization to a cDNA microarray. BMC Genomics 5:42(1-13). PDF


    Hofmann HA (2003) Functional Genomics of Neural and Behavioral Plasticity. Journal of Neurobiology 54: 272-282. PDF


    Hofmann HA, Schildberger K (2001) Assessment of strength and willingness to fight during aggressive encounters in crickets. Animal Behaviour 62:337-348. PDF


    Hofmann HA, Fernald RD (2001) What cichlids tell us about the social regulation of brain and behavior. Journal of Aquariculture and Aquatic Sciences 9:17-31. PDF


    Hofmann HA, Fernald RD (2000) Social status controls somatostatin-neuron size and growth. Journal of Neuroscience 20:1248-1252. PDF


    Stevenson PA, Hofmann HA, Schoch K, Schildberger K (2000) The fight and flight responses of crickets depleted of biogenic amines. Journal of Neurobiology 43:107-120. PDF


    Hofmann HA, Stevenson PA (2000) Flight restores fight in crickets. Nature 403:613. PDF


    Hofmann HA, Benson ME, Fernald RD (1999): Social status regulates growth rate: Consequences for life-history strategies. Proceedings of the National Academy of Sciences USA 95:14171-14176. PDF


    Hofmann HA, Rickli H (1999): Modellspur - Spurenmodell: Das Spannungsfeld zwischen Biologie und Kunst (German). In: Geus A, Rheinberger HJ, Riedl-Dorn C, Weingarten M. (eds.): Repräsentationsformen in den biologischen Wissenschaften. Verlag Wissenschaft & Bildung, Berlin: 51-58. PDF


Department of Integrative Biology  |  UT Austin-School of Biological Sciences  |  |  (512) 475-7318